Electrically enhanced and controlled drug delivery through buccal mucosa.
نویسندگان
چکیده
منابع مشابه
Preparation of Diphenhydramine Hydrochloride Mucoadhesive Oral Film and the Evaluation of its Pharmaceutics characteristics
Background & Objective: In recent years, mucoadhesive drug delivery systems has shown interested for prolonging the residence time of the dosage form and for providing a controlled rate of drug release. Mucoadhesive buccal films can enhance drug bioavailability by absorption through buccal mucosa and bypassing the first pass metabolism for improved therapeutic effect.. In addition, buccal films...
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The buccal mucosa is one of the administration sites that might provide an alternative for peroral administration. Mucoadhesive buccal drug delivery systems is one of the most important novel drug delivery systems with its various advantages and it has a lot of potential in formulating dosage forms for various chronic diseases. The delivery of drugs through the buccal mucosa has attracted much ...
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Owing to the ease of the administration, the oral cavity is an attractive site for the delivery of drugs. Through this route it is possible to realize mucosal (local effect) and transmucosal (systemic effect) drug administration. In the first case, the aim is to achieve a site-specific release of the drug on the mucosa, whereas the second case involves drug absorption through the mucosal barrie...
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Buccal delivery involves the administration of the desired drug through the buccal mucosal membrane lining of the oral cavity.The objective of this article is to review buccal drug delivery by discussing the structure and environment of the oral mucosa and highlighting the mechanisms of drug permeation and methodology in evaluating buccal formulations. This review also highlights a brief descri...
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Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...
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ورودعنوان ژورنال:
- Acta poloniae pharmaceutica
دوره 65 6 شماره
صفحات -
تاریخ انتشار 2008